The development of an immune-inflammatory response during periodontitis in the susceptible individual results in local production of a variety of inflammatory mediators including IL-1, IL-6 and tumor necrosis factor- (TNF- ), synthesis, and release of prostaglandins and other arachidonic acid metabolites within periodontal tissues. In addition the host cells stimulated the matrix metalloproteinases by a variety of infiltrating and resident cells. Host cells further release mediators including r ...